Are women using hormone replacement therapy at risk for other health conditions?

Yes: The estrogen hormone increases the risk of deep vein clots, a dangerous condition, to about twice the baseline rate. It also increases the risk of cancer of the uterus unless combined with a Progesterone hormone. This combination protects the uterus but somewhat increases the risk of breast cancer, an effect not seen with estrogen alone. Hormone replacement also increases the risk of bleeding.

Yes, but...: Remember that Estradiol levels are much higher during ovulation than those typically achieved during hrt. The focus has primarily been on the negative aspects of hrt rather than the health benefits. That's an inflammatory reaction to hrt, ignoring all the positive aspects of hrt. See a physician that focuses on the positive, while monitoring for the negative.