I've been in talk therapy for awhile and on two different meds and i still get depressed and don't want to do anything i lose interest?

It sounds like your: Depression is only partially treated at this point. Have you enganged in cognitive behavioral therapy ? - that might help you to get out of the rut.

Treat depression: Different treatments work for different people and even for the same person at different times in life. In addition to various medications and therapy, now there also is an fda-approved non-medication treatment for treatment resistant depression: transcranial magnetic stimulation (tms). Tms acts like physical erapy for the brain. It heals and limits the need for other treatments.