Question 1

why does excessive perspiration occur in osteogenesis imperfecta?

Accepted Answer

Thin skin: Oi affects bones and collagen, which makes up a large part of the skin.  People with oi have thin skin and as a result, higher normal body temperatures (by 1-2 degrees).  They can be more sensitive to both heat and cold, and need to sweat more to reduce their body temperature.

Question 2

could anybody get osteogenesis imperfecta?

Accepted Answer

No: It's a genetic disease, u do not get it as in infection.

Question 3

does a karyotype show osteogenesis imperfecta?

Accepted Answer

No: A karyotype is useful for detecting chromosomal abnormalities where the number of actual chromosomes is abnormal (e.g., Down syndrome or turner syndrome) or a large defect in a chromosome (like a duplication or translocation).  Oi is caused by small mutations in a number of possible genes.  There are some prenatal tests available for oi.

Question 4

what type of inheritance for osteogenesis imperfecta?

Accepted Answer

Autosomal dominant: Which means one copy of the altered gene in each cell is sufficient to cause the condition. 
And less comnnly autosomal recessive type of inhertance which means two copies of the gene in each cell are altered. The parents of a child with an autosomal recessive disorder typically are not affected, but each carry one copy of the altered gene.

Question 5

what is the medical definition of osteogenesis imperfecta?

Accepted Answer

See below: Osteogenesis imperfecta (oi) is a congenital disease that is present at birth. It is commonly caused by genetic defect in type 1 collagen, a building block of bone. There are various defects that can affect this gene. The severity of OI depends on the specific defect in the gene. OI is an autosomal dominant disease.

Question 6

which organ systems are affected by osteogenesis imperfecta?

Accepted Answer

Collagen formation: Oi refers to a group of individual genetic errors, which are associated with a variety of collagen formation.  Collagen is the mechanical foundation of body structure. Since the structure of bone depends on the mineralization of a complex called osteoid which is based on collagen, skeletal abnormalities, including deformity and fragility, are one of the most distressing characteristics of oi.

Question 7

what is the  inheritance pattern for osteogenesis imperfecta?

Accepted Answer

Autosomal dominant.: Autosomal dominant mutations in col1a1/col1a2 genes account for 90% of osteogenesis imperfecta cases.

Question 8

can you have osteogenesis imperfecta and serve in the military?

Accepted Answer

Depends: This probably depends on the level and severity of OI.  I do not truly know the answer to this, but my guess is probably for even type one OI the mildest form, this would probably preclude military service.

Question 9

is osteogenesis imperfecta can be inherent by all your children?

Accepted Answer

Possibly: This autosomal dominant disorder has a 50% per pregnancy transmission risk. Every conception may pass the disorder. So in fact, every child of an affected person could have the disorder or every child may be free of the disorder. In a series of a million pregnancies, statistically, half would & half would not.

Question 10

what are possible complications that arise from osteogenesis imperfecta?

Accepted Answer

It depends: Osteogenesis imperfecta is a group of disorders that cause bone fragility due to an error in the genetic code for type i collagen. All tissues that are composed of type i collagen are affected. There are many subtypes ranging in severity and associated comorbidities, but all include fragile bones. Among other systems that can be affected are dental and auditory systems.

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Why does excessive perspiration occur in osteogenesis imperfecta

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Why does excessive perspiration occur in osteogenesis imperfecta?

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Could anybody get osteogenesis imperfecta?

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Does a karyotype show osteogenesis imperfecta?

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What type of inheritance for osteogenesis imperfecta?

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What is the medical definition of osteogenesis imperfecta?

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Which organ systems are affected by osteogenesis imperfecta?

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What is the inheritance pattern for osteogenesis imperfecta?

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Can you have osteogenesis imperfecta and serve in the military?

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Is osteogenesis imperfecta can be inherent by all your children?

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What are possible complications that arise from osteogenesis imperfecta?

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