Which organ systems are affected by osteogenesis imperfecta?

Collagen formation: Oi refers to a group of individual genetic errors, which are associated with a variety of collagen formation. Collagen is the mechanical foundation of body structure. Since the structure of bone depends on the mineralization of a complex called osteoid which is based on collagen, skeletal abnormalities, including deformity and fragility, are one of the most distressing characteristics of oi.

Bones teeth eyes: Brittle bones poor dentition and blue sclerae (whites of the eyes) are common features of oi.

Many: Although the primary manifestation of oi is often fractures, there are multiple other associated issues for some people ranging from short stature to problems with hearing to blood vessel fragility to joint laxity to issues with teeth etc. Great information can be found on the oi foundation website. www.oif.org.