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A 29-year-old member asked:

What is the inheritance pattern for osteogenesis imperfecta?

1 doctor answer3 doctors weighed in
Dr. Nikolaos Zacharias
Maternal-Fetal Medicine 26 years experience
Autosomal dominant.: Autosomal dominant mutations in col1a1/col1a2 genes account for 90% of osteogenesis imperfecta cases.

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A 36-year-old member asked:

What type of inheritance for osteogenesis imperfecta?

1 doctor answer2 doctors weighed in
Dr. Ahmad M Hadied
Orthopedic Surgery 49 years experience
Autosomal dominant: Which means one copy of the altered gene in each cell is sufficient to cause the condition. And less comnnly autosomal recessive type of inhertance which means two copies of the gene in each cell are altered. The parents of a child with an autosomal recessive disorder typically are not affected, but each carry one copy of the altered gene.
Dr. Linda DiMeglio
Pediatric Endocrinology 28 years experience
There are also autosomal recessive forms. Many forms are sporadic.
Mar 3, 2013
A 45-year-old member asked:

Can you tell me about osteogenesis imperfecta inheritance patterns?

1 doctor answer2 doctors weighed in
Dr. Jay Park
Dr. Jay Parkanswered
Pediatrics 50 years experience
Autosomal dominant: Osteogenesis impecta (OI) is transmitted in autosomal dominant fashion. Rare cases of OI, type II B & type II C, are transmitted in autosomal recessive inheritance.
A 34-year-old member asked:

How is osteogenesis imperfecta inheritanced?

1 doctor answer3 doctors weighed in
Dr. Jay Park
Dr. Jay Parkanswered
Pediatrics 50 years experience
Autosomal dominant: Osteogenesis impecta (OI) is transmitted in autosomal dominant fashion. Rare cases of OI, type II B &and type II C, are transmitted in autosomal recessive inheritance.
A 44-year-old member asked:

Please help! what is the mode of inheritance for osteogenesis imperfecta?

1 doctor answer3 doctors weighed in
Dr. Anna-Kaisa Niemi
Clinical Genetics 16 years experience
OI mostly dominant: There are many types of osteogenesis imperfecta. Most are inherited in an autosomal dominant pattern (=one copy of the altered gene sufficient to cause condition). Some inherit it from a parent, others arise spontaneously (sporadic, de novo) in a child. Some types of oi are inherited in autosomal recessive manner which means that each parent is a carrier but does not have symptoms.

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Last updated Jul 22, 2012

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