Question 1

what is the relationship of her2 and p53 with hormone receptors in breast cancer?

Accepted Answer

Complicated: Her-2 is an oncogene usually (not always) associated with er- tumors. We know that it is in general associated with a worse prognosis, but women with her 2+ tumors may respond dramatically to Herceptin (trastuzumab) - a monoclonal antibody.  P53 is a tumor suppressor gene. The relationship between p53 and er is currently under study - it may be that p53 mutations may play a role in tamoxifen responsiveness.

Question 2

can pain in breasts mean i have breast cancer?

Accepted Answer

Not usually: Brian I am assuming you are male.  Breast pain and lump in a male is usually a non cancerous condition called gynecomastia.  It is a hormonal side effect of many medications in adult males but is seen during normal hormonal changes during puberty.  You should be examined and a mammogram and/or sonogram may be needed to confirm that it is gynecomastia.

Question 3

what does it mean if breast cancer is in stage 0?

Accepted Answer

Stage 0: Means non-invasive very early breast cancer. Generally has an excellent long term prognosis.

Question 4

could there be a connection between breast cancer and abortion?

Accepted Answer

No: But there is a connection with number of pregnancies, ( more is protective) age of the woman, hormone therapy, alcohol, smoking, family history (genetic factors) etc. Etc. Are few among the many other risk factors. Statistically according to some 1 in 7 women will come down with the condition, thus early dg is imperative!

Question 5

supposing you have a tumor on your breast. does it mean you have breast cancer?

Accepted Answer

No: Definition of tumor is a lump. Most breast lumps are not cancer but they should be evaluated properly, especially in they are changing. If you have any doubt about a breast lump, see your doc please.

Question 6

breast cancer staging according tnm means what?

Accepted Answer

TNM breast cancer: Tnm is one of the staging system commonly used for cancer. It stands for t-tumor ( the size of the tumor- the bigger is the tumor the higher is the stage) ; n- nodal status ( involvement to the lymph glands) - and m-  presence of metastatic disease to the distant organ. See more here: http://cancer.Gov/cancertopics/wyntk/breast/page7.

Question 7

what does metastatic breast cancer really mean?

Accepted Answer

Cancer has spread: Metastatic, or stage 4 breast cancer, means the cancer has spread into other places in the body.  Breast cancer at this stage can be treated, sometimes for 10 or more years depending on the type, but it cannot be cured.

Question 8

could dense breast tissue mean you must have breast cancer?

Accepted Answer

No, not necessarily: Dense breasts are a common finding in mammograms of younger females. It is really a physiologic effect of hormones. As women age breasts become less dense. Breast cancer can be more difficult to detect in dense breasts, so an ultrasound examination is often added to mammography in order to get a more detailed look inside the breast.

Question 9

what do er and her2 positive mean in relation to breast cancer?

Accepted Answer

See below: Estrogen receptor (er) is measured to determine whether a tumor is sensitive to hormonal manipulation (things like tamoxifem, arimidex, or removal of ovaries - depending on your age and other factors.  Er+ tumors have better prognosis.  In general her2 + tumors have a worse prognosis, but these tumors may respond to Herceptin (trastuzumab) or similar drugs.

Question 10

could clusters of microcalcifications mean you have breast cancer?

Accepted Answer

Sometimes yes: Depending on the appearance, but this is a finding on mammogram.  A biopsy is required to arrive at a definite diagnosis.

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What does architecture mean in relationship to breast cancer

A member asked:

What is the relationship of her2 and p53 with hormone receptors in breast cancer?

A member asked:

Can pain in breasts mean i have breast cancer?

A member asked:

What does it mean if breast cancer is in stage 0?

A member asked:

Could there be a connection between breast cancer and abortion?

A member asked:

Supposing you have a tumor on your breast. does it mean you have breast cancer?

A member asked:

Breast cancer staging according tnm means what?

A member asked:

What does metastatic breast cancer really mean?

A member asked:

Could dense breast tissue mean you must have breast cancer?

A member asked:

What do er and her2 positive mean in relation to breast cancer?

A member asked:

Could clusters of microcalcifications mean you have breast cancer?

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