Question 1

is scid a problem with the chromosomes?

Accepted Answer

Yes: There are several different problems with chromosomes that lead to severe combined immunodeficiency disease (scid).

Question 2

what chromosome is scid associated with?

Accepted Answer

X-linked SCIDs assoc: Mutations in 9 different genes have been found to cause the human scids. The products of 3 of the genes: 2rg, jak3, and il-7rα -are components of cytokine receptors, and 3 more: rag1, rag2, & artemis -are essential for effecting antigen receptor gene rearrangement. A deficiency of cd3δ, a component of the t-cell antigen results in a near absence of circulating mature cd3+ & complete lack of γ/δ tc.

Question 3

what kind of mutation occurs in scid disease?

Accepted Answer

Depends: There are too many different types of scid - severe combined immunodeficiency for there to be just one mutation.  Scid is commonly referred to as "bubble boy" disease in the lay press.  The most common type is linked to the x chromosome and causes a defect in t cells and natural killer cells.

Question 4

what goes wrong with your genes when you have scid?

Accepted Answer

Immune deficiency: Severe combined immunodeficiency (scid) usually has a genetic cause, particularly involving genes for enzymes that recycle dna precursors like Adenosine deaminase or nucleotide phosphorylase (enter omim in your browser, search on scid to see these and other genes). Bone marrow transplant and in rare cases gene transplant (gene therapy) can cure these conditions and prevent a "bubble-boy" existence.

Question 5

are there any causes besides genetics of developing scid?

Accepted Answer

Yes: If you have received the diagnosis of genetic severe combined immunodeficiency, implying mutations in specific genes, then it is strictly genetic. If you have less defined deficiencies of t-cells (viral. Fungal defense) or b-cells/immunoglobulins (bacterial defense), these can be acquired (e.g., aids) or transient (e.g., hypoglobulinemias) due to chemicals, infections, or cancer.

Question 6

what are the signs of scid?

Accepted Answer

Serious infections: SCID is an immune deficiency present at birth. MDs think about this when infants have several serious illness early on. Texas tests for this on their newborn screens to help in early detection. This article may help answer more of your questions.

http://www.scid.net/

Question 7

how long could someone with scid live?

Accepted Answer

Depends: Depends on which type of scid they have and more importantly when they are diagnosed and treatment begun.  The earlier the recognition is, the less complications and infections the infant will have and the better the outcome.

Question 8

how long will someone survive with scid?

Accepted Answer

Depends on treatment: Without treatment, an infant with scid will not survive more than a couple of years after birth. Treatment with bone marrow transplantation, enzyme replacement, or gene therapy can potentially lead to a normal life span. However, outcomes are best if treatment is started early, before the infant develops infections. Even in the best case, regular follow up with an immunologist is suggested.

Question 9

can you tell me everything to know about scid.?

Accepted Answer

Early Diagnosis: Severe Combined Immunodeficiency (SCID) is a genetic disorder causing  severe dysfunction of the immune response to infections (bacteria, viruses, and fungi). Several disease variants occur and symptoms can differ however most children die during their first 2 yrs from infection without treatment. Bone marrow transplant is curative. Early diagnosis and treatment are key to survival.

Question 10

what kind of inheritance pattern does scid have?

Accepted Answer

Autosmal recessive: The genetic forms of severe combined immunodeficiency are caused by enzyme deficiencies, with affected individuals having two abnormal genes at the enzyme locus. Parents will have one normal and one abnormal gene with 50% enzyme activity (enough to produce immune cells).  Parents will have a 25% risk for scid with each future pregnancy.

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Doctor answers about:

Scid life expectancy

A member asked:

Is scid a problem with the chromosomes?

A member asked:

What chromosome is scid associated with?

A member asked:

What kind of mutation occurs in scid disease?

A member asked:

What goes wrong with your genes when you have scid?

A member asked:

Are there any causes besides genetics of developing scid?

A member asked:

What are the signs of scid?

A member asked:

How long could someone with scid live?

A member asked:

How long will someone survive with scid?

A member asked:

Can you tell me everything to know about scid.?

A member asked:

What kind of inheritance pattern does scid have?

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