X-linked SCIDs assoc: Mutations in 9 different genes have been found to cause the human scids. The products of 3 of the genes: 2rg, jak3, and il-7rα -are components of cytokine receptors, and 3 more: rag1, rag2, & artemis -are essential for effecting antigen receptor gene rearrangement. A deficiency of cd3δ, a component of the t-cell antigen results in a near absence of circulating mature cd3+ & complete lack of γ/δ tc.
Answered 10/24/2017
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