Question 1

a person has pnh, normocellular bone marrow, but has falling neutrophils and platelets. no mds or other clonal disorder. r/o what else?

Accepted Answer

Complicated: Likely more info needed and too complicated to answer here.
With normocellular bone marrow and low peripheral blood counts, consider autoimmune mechanism (itp for platelets). Also look at pnh status.

Question 2

what is bone marrow?

Accepted Answer

Home of blood cells: The cells in your blood are born and reach maturity in the bone marrow. This is the very protected space in the middle of your large bones like your arms, legs, hips and back. Once the cells are mature, they are released into the blood stream where they travel throughout the body preventing infection (granulocytes, lymphocytes), supply oxygen (red cells) and prevent bleeding (platelets).

Question 3

how is bone marrow donated?

Accepted Answer

Under gen anesthesia: Donating bone marrow for transplantation entails a procedure called bone marrow harvesting. The donor is placed under general anesthesia and turned over to lie on his/her belly to expose the hip bones on the back. Multiple aspirations of bone marrow are collected (average about 1 liter) at adjacent sites on the hip bone on both sides until a particular number of cells are reached.

Question 4

is it painful to give bone marrow?

Accepted Answer

It can be: If bone marrow is collected the standard way by retrieving it directly from a bone, it can be painful due to pressure when the needle is inserted into the bone. If the cells are collected from the blood, it can be mildly painful after you get the medication to mobilize the marrow cells from within the bone to the blood circulation. The method used depends on the situation at hand.

Question 5

how can  donating bone marrow work?

Accepted Answer

Register as a Donor: You can register in any blood bank by asking about the national marrow donor program(nmdp) also called: be the match registry. It is simple to register as a potential donor by giving a sample of body cells, usually taken from inside of your cheek. Once they find your body cells match someone in need they will call you to donate your blood stem cells or marrow stem cells.

Question 6

any benefit from eating bone marrow?

Accepted Answer

No: No, no health benefit. But, if prepared well as in osso bucco, it can be delicious when spread on little toasts.

Question 7

what is a bone marrow test used for?

Accepted Answer

Detecting diseases: Bone marrow tests are performed for many reasons, but the commonest ones are:
detecting bone marrow involvement by a cancer - many cancers, notably lymphomas spread from their primary site to different organs of the body, including the bone marrow
detecting cancers of the blood leukemias 
finding the cause of anemia. 
Bone marrow infiltration by other diseases

Question 8

what is the hypercellular bone marrow?

Accepted Answer

The bone marrow: Changes as we age. The cellularity is the percentage of blood cell production as compared to fat. As a rule of thumb the cellularity as a percent is 100 - your age. Hypercellularity means that number is higher than expected.

Question 9

how is a bone marrow match determined?

Accepted Answer

HLA type: Every cell in your body has human leukocyte antigens (hlas) on the surface that act like a cell i.D. These allow your immune cells to recognize your cells as part of you and not foreign cells that need to be attacked. The bone marrow donor's hlas should match the patient's hlas as closely as possible so the donor's immune system doesn't attack the patient!  hla is determined by a blood test.

Question 10

how do i got about donating bone marrow?

Accepted Answer

Go to a blood bank: Most hospitals have blood banks and they know how to register you to donate a sample of blood or cells from a cheek swab for matching. Thye will register you at the national marrow donor program(nmdp). You can also look up nmdp or...Be the match program in the internet and find more information.

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Doctor answers about:

Normocellular bone marrow

A member asked:

A person has pnh, normocellular bone marrow, but has falling neutrophils and platelets. no mds or other clonal disorder. r/o what else?

A member asked:

What is bone marrow?

A member asked:

How is bone marrow donated?

A member asked:

Is it painful to give bone marrow?

A member asked:

How can donating bone marrow work?

A member asked:

Any benefit from eating bone marrow?

A member asked:

What is a bone marrow test used for?

A member asked:

What is the hypercellular bone marrow?

A member asked:

How is a bone marrow match determined?

A member asked:

How do i got about donating bone marrow?

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