Question 1

neonatal alloimune thrombocytopenia, what is this?

Accepted Answer

Low platelets count: Neonatal alloimmune thrombocytopenia occurs when fetal platelets contain an antigen inherited from the father that the mother lacks. The mother forms antiplatelet antibodies against the this antigen; these cross the placenta and destroy fetal platelets, resulting in fetal and neonatal thrombocytopenia. Minority of affected newborns  (about 20%) experiences severe bleeding including intracranial bl

Question 2

what does neonatal alloimune thrombocytopenia mean?

Accepted Answer

NAT: Neonatal (fetus or newborn under 1 month)
 alloimmune (immune response to foreign antigen)
thrombocytopenia (low platelet count).

NAT occurs when substances from mother's body pass into the baby's system, causing destruction of platelet cells.

Question 3

neonatal alloimune thrombocytopenia treatment?

Accepted Answer

Platelet transfusion: If the fetus has an antigen on platelets that the mother lacks, she may make antibodies that destroy the fetal platelets.  Infusing platelets that lack the antigen is the treatment. Platelets can be infused into the fetus in utero, if needed, .

Question 4

newborn with low platelets, what is diagnosis?

Accepted Answer

Thrombocytopenia: The name of the condition is thrombocytopenia. If real (test can be a false positive) the condition usually arises when the mom develops anti platelet antibodies that have crossed into baby & destroy its platelets. The condition can be major requiring rx or minor & will generally fade over time as the antibodies  decline. Low platelets can also be a sign of infection in baby.

Question 5

is thrombocytopenia hereditary?

Accepted Answer

Can be in some cases: Thrombocytopenia (low platelet count) has many possible causes, but most are not inherited.  Inherited types include wiskott-aldrich syndrome and the rare giant platelet disorders.

Question 6

can you die from thrombocytopenia?

Accepted Answer

It can cause Bleedin: Severe thrombocytopenia can cause hemorrhage which can at times be fatal. But the platelet count has drop below 10, 000 before there is such a risk.

Question 7

what are the tests for thrombocytopenia?

Accepted Answer

CBC and further: A complete blood cell count (CBC) includes the number of platelets in blood.  Normal range is from about 150k to 250 k.  There is usually no risk of bleeding if the count is above 40k.  If thrombocytopenia is detected, it would require further investigation to ascertain the cause.

Question 8

what are the symptoms of thrombocytopenia?

Accepted Answer

Bleeding: Normal platelet counts are 150-250 k.  Usually there are no symptoms if the count is above 40 k.  Below that there may be pin point or larger bleeding sites in the mucus membrane or skin.  In newborns there may be bleeding in the brain.  Other abnormal bleeding may be nose bleed, excessive menstrual bleeding, bleeding in the intestine etc.

Question 9

what's thrombocytopenia and how can it be treated?

Accepted Answer

Depends on cause: Thrombocytopenia refers to low platelet count, a blood cell type needed for normal control of bleeding. Treatment depends on the  cause of the abnormality. Some times platelets are transfused, like blood transfusion,  to correct bleeding due to low platelet count.

Question 10

is thrombocytopenia curable?

Accepted Answer

Depends on cause: Easily treatable causes of thrombocytopenia include drugs and infections. Thrombocytopenia due to bone marrow problems (cancer, myelodysplastic syyndrome, etc.) and autoimmune problems are harder to treat.

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Neonatal thrombocytopenia

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Neonatal alloimune thrombocytopenia, what is this?

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Newborn with low platelets, what is diagnosis?

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