Question 1

how are bone marrow biopsy and chromosome analysis different?

Accepted Answer

There is big differe: Bone marrow biopsy is done to obtain a pice of tissue to look under the microscope and find out if the blood formation is normal or abnormal.
Chromosomes are not visible in the standard bone marrow biopsy. For this we need to culture the blood cells and capture the chromosomes when they are well formed just before the cells divide. This test takes a laboratory which can culture blood cells to see.

Question 2

what are the differences between bone marrow biopsy and chromosome analysis?

Accepted Answer

Different : A bone marrow biopsy is a sampling of the marrow for a host of diagnostic workups.  A chromosome analysis entails looking at the genes and structure within the nucleus of a cell.  They may come from the bone marrow if needed.

Question 3

is a bone marrow biopsy better than a chromosome analysis to diagnose blood cancer?

Accepted Answer

Yes: Usually, when a bone marrow biopsy/aspirate is done, additional material is collected for special testing, such as flow cytometry and chromosome analysis.  While the most important information is obtained by microscopically examining the cells in the bone marrow, the results of those special studies can help the pathologist more specifically diagnose the cancer, if one is present.

Question 4

is the blood draw for fragile x testing a chromosomes test?

Accepted Answer

Yes: Cytogenetic examination is one way of making the diagnosis.

Question 5

how is it possible for a blood test find a male "y" chromosome in a females blood after she got a kidney transplant?

Accepted Answer

Microchimerism: The leukocytes in the transplanted kidney may enter the circulation of the recipient and stay there for years.  If the donor was a male the circulating lymphocytes form the donor would carry a y chromosome.

Question 6

what are some reasons for a second trimester miscarriage beside chromosomes, blood clotting, uterine issues, and autoimmune?

Accepted Answer

That is most: Another cause could be an incompetent cervix, anesthesia or radiation exposure or other toxin exposure.  If this is a repetitive thing for you, you should see a specialist who can work you up for potential causes and treat them.

Question 7

i am 12 weeks pregnant. blood tests show low papp-a of 0.27 mom. elected to have nipt for chromosomal abnormalities. what are chances of other risks of low papp-a like miscarriage, low birth weight, prematurity, pre-eclampsia? advised management?

Accepted Answer

PAPP-A results ?'s: A PAPP-A level below 0.40 suggests a higher risk of late miscarriage, low birth weight/prematurity.  With this result, request a referral to a MFM (maternal fetal medicine) specialist to closely monitor this pregnancy.  None of the associated problems may occur, but it is best to have increased monitoring to plan later interventions necessary in this pregnancy.

Question 8

while pregnant son had neonatal stroke. etiology unknown(blood disorders ruled out) could i have had stroke if not pregnant?

Accepted Answer

Probably not: There are many causes for a stroke in newborn infants and they are rare. If the clotting disorder was ruled out-there may have been an anatomical or other reason for it that have nothing to do with your risk of having a stroke. I am assuming that your pregnancy was uneventful.

Question 9

are complete blood cell counts useful in the evaluation of asymptomatic neonates exposed to suspected chorioamnionitis?

Accepted Answer

Perhaps: A CBC could show an elevated white blood cell count, which could be concerning for an infection. Though typically, an infected infant will have either a fever or temperature instability (low temp) - in others words could be symptomatic.

Question 10

is it possible to give blood transfusion {packed red blood cells} through an arterial femoral line for the neonates?

Accepted Answer

Possible, but why?: It is not commonly done to put fluids into an arterial line, that usually is used for pressure monitoring and to obtain blood for testing. Could be done on a pump in theory. Usually would use a peripheral or central venous line to transfuse. Neonates may be only accessible vessel due to small size.

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Doctor answers about:

Neonatal blood chromosome analysis

A member asked:

How are bone marrow biopsy and chromosome analysis different?

A member asked:

What are the differences between bone marrow biopsy and chromosome analysis?

A member asked:

Is a bone marrow biopsy better than a chromosome analysis to diagnose blood cancer?

A member asked:

Is the blood draw for fragile x testing a chromosomes test?

A member asked:

How is it possible for a blood test find a male "y" chromosome in a females blood after she got a kidney transplant?

A member asked:

What are some reasons for a second trimester miscarriage beside chromosomes, blood clotting, uterine issues, and autoimmune?

A member asked:

I am 12 weeks pregnant. blood tests show low papp-a of 0.27 mom. elected to have nipt for chromosomal abnormalities. what are chances of other risks of low papp-a like miscarriage, low birth weight, prematurity, pre-eclampsia? advised management?

A member asked:

While pregnant son had neonatal stroke. etiology unknown(blood disorders ruled out) could i have had stroke if not pregnant?

A member asked:

Are complete blood cell counts useful in the evaluation of asymptomatic neonates exposed to suspected chorioamnionitis?

A member asked:

Is it possible to give blood transfusion {packed red blood cells} through an arterial femoral line for the neonates?

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