Question 1

what is/are the best test(s) for detecting a monoclonal plasma cell disorder? how sensitive are these tests? which types of mpcds can they detect?

Accepted Answer

SPEP: The best test is a serum protein electrophoresis.  It is very sensitive and specific.  The disease is rare in anyone under the age of 40.  For the vast majority of people the disease does not progress for many years 10-20+  so there is no role for screening.

Question 2

what causes monoclonal paraproteinemia?

Accepted Answer

Excess of Plasma cel: Plasma cells in our bone marrow make antibodies. Sometimes they become overly active/reactive and produce abnormal proteins called paraproteins. Most such protein production is benign and not uncommon in older folks. Sometimes it is excessive(more than 1gram/day) then we get concerned about a condition called multiple myeloma (paraproteins over 3 grams).

Question 3

monoclonal proteinemia, what is it?

Accepted Answer

Excessive : Amounts of one type of protein in blood. 
It is usually the reflection of increased production, although abnormal protein structure or impaired destruction may play a role. Check with your doctor for additional details regarding your particular situation.

Question 4

what is monoclonal gammopathy about?

Accepted Answer

Please read below: According to mayo clinic.Monoclonal gammopathy of undetermined significance (mgus) is a common precancerous condition affecting people 50 years of age and older. It was first described by mayo clinic researchers in 1978 and is characterized by the presence of an abnormal protein in the blood called a (monoclonal) protein. Has(1 percent each year) of progressing to a blood cancer muliple myloma.

Question 5

what can cause monoclonal gammopathy?

Accepted Answer

Mayo Clinic say: Plasma cells are a type of white blood cell. They are found in your bone marrow. Plasma cells produce some of the antibodies that help your body fight infection. Monoclonal gammopathy of undetermined significance occurs when plasma cells in your bone marrow produce an abnormal protein called monoclonal protein (m protein).

Question 6

are igg lambda monoclonal bands common?

Accepted Answer

IgG lambda rare: Only 20% of all human igg use lambda light chains. Monoclonal bands are not common in general and may be benign or a sign of myeloma. Most a kappa.

Question 7

what's monoclonal gammopathy of undetermined significance?

Accepted Answer

MGUS: Is a common precancerous condition affecting people 50 years of age and older. It was first described by mayo clinic researchers in 1978 and is characterized by the presence of an abnormal protein in the blood called a (monoclonal) protein or m protein.Mgus has a small risk (1 percent each year) of progressing to a blood cancer called multiple myeloma or a related condition.

Question 8

what are the differences between monoclonal and polyclonal antibodies?

Accepted Answer

Antibody clonality: Each antibody molecule recognizes a specific target.  A collection of identical antibodies that all recognize the exact same target is monoclonal.  A collection of antibodies that each recognize different targets is polyclonal.  For example, if you have a polyclonal antibody against bacteria, all the antibodies attach to the bacteria but at different locations on it.

Question 9

can i treat a possible monoclonal gammopathy of undetermined significance at home?

Accepted Answer

Nope: You don't treat an mgus, it is a condition that can ultimately lead to multiple myeloma (risk is about 1% per year) but as of itself does not need therapy (assuming it was correctly diagnosed).  You need to have labs checked at least 1 or 2 times a year so you should follow up with your doc indefinitely.

Question 10

what is the definition or description of: monoclonal gammopathy of undetermined significance?

Accepted Answer

A monoclonal: Gammopathy is an elevation in a specific type of immune protein in the blood.  The work-up includes tests of urine protein, bones and blood production.  If no serious associated disease is found then the clinical finding is called mgus.  The patient is followed over time to see if the gammopathy becomes "significant."  some patients declare themselves later with multiple myemoma or lymphoma.

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A member asked:

What is/are the best test(s) for detecting a monoclonal plasma cell disorder? how sensitive are these tests? which types of mpcds can they detect?

A member asked:

What causes monoclonal paraproteinemia?

A member asked:

Monoclonal proteinemia, what is it?

A member asked:

What is monoclonal gammopathy about?

A member asked:

What can cause monoclonal gammopathy?

A member asked:

Are igg lambda monoclonal bands common?

A member asked:

What's monoclonal gammopathy of undetermined significance?

A member asked:

What are the differences between monoclonal and polyclonal antibodies?

A member asked:

Can i treat a possible monoclonal gammopathy of undetermined significance at home?

A member asked:

What is the definition or description of: monoclonal gammopathy of undetermined significance?

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