Question 1

i had a serum immunofixation and serum electrophoresis run and the interpretation was suspicious of monoclonal gammopathy and igg lambda. what does this mean? the beta and gamma globulin where at 0.6 and 0.7 g/dl?

Accepted Answer

: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. Having said that, such a finding is not uncommon with advancing age. Your doctor will probably repeat the test a 6-12 months to assess if the monoclonal IgG lambda is increasing.    
Wish you good health!

Question 2

free kappa light chain is high, flc ratio is 2.205, no monoclonal gammopathy. iga 389.43, lgm 125.95 and lgg 1771.02 h. should we be worried? thanks.

Accepted Answer

No: Abnormal FLC ratio is not diagnostic of any disease. More than 50% of the people with increased levels of gamma globulins have abnormal FLC ratio without a disorder of the plasma cells.

Question 3

can a igm kappa light chain monoclonal gammopathy turn into macroglobulinemia?

Accepted Answer

IgM is macroglobulin: Macroglobulinemia is the term for monoclonal igm. However what you described is confusing/erroneous term, igm kappa is not light chain gammopathy. Igm kappa, by definition is macroglobulin.

Question 4

i had a blood test done, what does it mean? kappa monoclonal gammopathy. is this rare? does this mean cancer? is this anything to worry about?

Accepted Answer

If : If you don't already have an appointment with the doctor who ordered these blood tests you should make one to go over the results.

Hopefully you have what is called monoclonal gammopathy of unknown significance (mgus).  This is a fairly common precancerous condition.  It has a low risk of about 1% per year of turning into a cancerous condition called multiple myeloma or a related plasma cell tumor.  Additional tests might be needed to determine if this is the condition you have or if the disease is more advanced.

Question 5

what can cause monoclonal gammopathy?

Accepted Answer

Mayo Clinic say: Plasma cells are a type of white blood cell. They are found in your bone marrow. Plasma cells produce some of the antibodies that help your body fight infection. Monoclonal gammopathy of undetermined significance occurs when plasma cells in your bone marrow produce an abnormal protein called monoclonal protein (m protein).

Question 6

what's monoclonal gammopathy of undetermined significance?

Accepted Answer

MGUS: Is a common precancerous condition affecting people 50 years of age and older. It was first described by mayo clinic researchers in 1978 and is characterized by the presence of an abnormal protein in the blood called a (monoclonal) protein or m protein.Mgus has a small risk (1 percent each year) of progressing to a blood cancer called multiple myeloma or a related condition.

Question 7

is mononuclueosis associated at all with monoclonal gammopathy?

Accepted Answer

No: Ebv  infection, the cause of mononucleosis is not usually related to monoclonal gammopathy. Ebv induced lymphoma may produce monoclonal gammopathy, but that would be an uncommon situation.

Question 8

iga lambda monoclonal gammopathy meaning?

Accepted Answer

It is a medical diso: A medical disorder where your body is making excess of proteins(Gamma Globulins). It can manifest in 2-3 different ways(MGUS or Multiple Myeloma). So you need your doctor to explain which of these conditions do you have and theen get further testing, monitoring and you may or may not need treatment depending on whether it is mGUS(early) or Myeloma(later developemnt...that is a type of Blood Cancer

Question 9

can monoclonal gammopathy cause osteomyelitis?

Accepted Answer

Not realy: It's estimated that between 10 and 25 percent of people with monoclonal gammopathy of undetermined significance develop a more serious condition, such as multiple myeloma or other cancers or blood disorders. Other complications  include fractures and blood clots.

Question 10

are any of (1) overlap myeloproliferative/myelodysplastictiy disorder (2) monoclonal b cell lymphocytosis or(3) monoclonal gammopathy ever familial?

Accepted Answer

Familial blood dx: Yes. there can be a familial component. Monoclonal gammopathies  in some cases may be increased in blood relatives 
Familial monoclonal gammopathy of undetermined significance and multiple myeloma: epidemiology, risk factors, and biological characteristics.
Greenberg AJ1, Rajkumar SV, Vachon CM. Blood. 2012 Jun 7;119(23):5359-66.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685083/
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Doctor answers about:

Monoclonal gammopathy igg kappa

A member asked:

I had a serum immunofixation and serum electrophoresis run and the interpretation was suspicious of monoclonal gammopathy and igg lambda. what does this mean? the beta and gamma globulin where at 0.6 and 0.7 g/dl?

A member asked:

Free kappa light chain is high, flc ratio is 2.205, no monoclonal gammopathy. iga 389.43, lgm 125.95 and lgg 1771.02 h. should we be worried? thanks.

A member asked:

Can a igm kappa light chain monoclonal gammopathy turn into macroglobulinemia?

A member asked:

I had a blood test done, what does it mean? kappa monoclonal gammopathy. is this rare? does this mean cancer? is this anything to worry about?

A member asked:

What can cause monoclonal gammopathy?

A member asked:

What's monoclonal gammopathy of undetermined significance?

A member asked:

Is mononuclueosis associated at all with monoclonal gammopathy?

A member asked:

Iga lambda monoclonal gammopathy meaning?

A member asked:

Can monoclonal gammopathy cause osteomyelitis?

A member asked:

Are any of (1) overlap myeloproliferative/myelodysplastictiy disorder (2) monoclonal b cell lymphocytosis or(3) monoclonal gammopathy ever familial?

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