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malaria selects for sickle cell anemia

A 54-year-old member asked:
Dr. Jeffrey Unger
40 years experience Family Medicine
No: Malaria is an infectious disease transmitted by mosquitoes. Sickle cell is a genetic disorder resulting in a disruption in the oxygen carrying capacit ... Read More

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A 44-year-old member asked:
Dr. Martin Raff
55 years experience Infectious Disease
Resistance: Red blood cells whose structure is altered by sickle cell trait or disease are more resistant to invasion by plasmodium spp., the organism which cause ... Read More
A 49-year-old member asked:
Dr. Michael Benjamin
22 years experience Hematology and Oncology
Malaria doesnt cause: Sickle cell anemia is a hereditary disease caused by a mutation in the dna coding for hemoglobin. Scientists have long known that sickle cell anemia ... Read More
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A 43-year-old member asked:
Dr. Donald Alves
23 years experience Emergency Medicine
No & "it depends": Depending on the setting--malaria is an infectious disease affecting red blood cells. Persons with sickle cell usually have more of a less common type ... Read More
A 29-year-old female asked:
Dr. Le Wang
Dr. Le Wang answered
35 years experience Internal Medicine
Most less severe: Most are less severe in sickle cell thalassemia, but depends. HbS/B(0)thal: similar to HbSS in severity maybe slightly less severe. HbS/B(+)thal: has ... Read More
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A 30-year-old member asked:
Dr. Jay Park
Dr. Jay Park answered
49 years experience Pediatrics
Chromosome No. 11: Point mutation at beta-globin gene located at chromosome no. 11 results in production of defective hemoglobin, sickle hemoglobin.
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A 30-year-old male asked:
Dr. Craig MacArthur
33 years experience Pediatric Hematology and Oncology
Probably not: Sickle cell patients are anemic because their red blood cells are destroyed earlier than normal red blood cells. Most sickle cell patients are not iro ... Read More
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A 37-year-old member asked:
Dr. Ankush Bansal
16 years experience Internal Medicine
No: Sickle cell anemia is not an infection - thus it is not contagious. It is a genetic disease and so, it is hereditary.
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A 48-year-old member asked:
Dr. James Ferguson
45 years experience Pediatrics
Yes: Or one with trait and one with ss.
A 42-year-old member asked:
Dr. Steven Ginsberg
36 years experience Hematology and Oncology
Genes: Sickle cell anemia occurs when someone has 2 sickle cell genes. Normal hemoglobin (hb) genes code for hb a. A sickle cell gene codes for hb s. Having ... Read More
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A 42-year-old member asked:
Dr. Joseph Torkildson
38 years experience Pediatric Hematology and Oncology
Not by itself: Women with sickle cell disease can have children safely depending on what active complications of sickle cell disease they have. This is complicated a ... Read More
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A 44-year-old member asked:
Dr. Liawaty Ho
22 years experience Hematology and Oncology
Sickle and malaria: Patients with sickle cell disease are protected against severe and complicated malaria infection- by 2 mechanism: -1. Cells infected with malaria pa ... Read More
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A 38-year-old member asked:
Dr. Joseph Torkildson
38 years experience Pediatric Hematology and Oncology
Only here in the US: If you compare a MAP of malaria prevalence (number of cases) to a MAP of sickle cell disease prevalence, they are almost super-imposable with one exce ... Read More
A 48-year-old member asked:
Dr. Scott Diede
28 years experience Pediatric Hematology and Oncology
No: The vast majority of patients with sickle cell trait have no health consequences whatsoever.
A 52-year-old member asked:
Dr. Michael Engel
19 years experience Pediatric Hematology and Oncology
Beta thalassemia: Is a quantitative deficiency of beta globin, caused by alterations in regulatory elements governing beta globin expression. The mutation that causes s ... Read More
A 40-year-old member asked:
Dr. Hushang Haghighat
Specializes in Pediatric Hematology and Oncology
NO: Hydroxyurea is not for treatment of sickle cell disease it is for treatment of malignancy disease.
A 41-year-old member asked:
Dr. Michael Engel
19 years experience Pediatric Hematology and Oncology
No: A diagnosis of sickle cell disease precludes donation of blood. This is not only because of the presence of the disease itself, but also because patie ... Read More
A 46-year-old member asked:
Dr. Ankush Bansal
16 years experience Internal Medicine
Yes: Sickle cell anemia is due to a genetic mutation in the dna that encodes for the hemoglobin molecule. Thus, it is hereditary.
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A 40-year-old member asked:
Dr. Michael Dugan
Specializes in Hematology
There are: Huge ranges of disease severity and associated symptoms. Careful choices and attention to medical recommendations will improve the prognosis.
A 30-year-old member asked:
Dr. Robert Kwok
32 years experience Pediatrics
Got both mutations: A person has sickle cell beta thalassemia if he inherited one gene mutation for sickle cell anemia, and also inherited one gene mutation for beta thal ... Read More
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A 30-year-old member asked:
Dr. Barbara A Majeroni
Specializes in Family Medicine
Hereditary: Sickle cell anemia is a hereditary condition where some of the red blood cells become sickle shaped and rigid, and can't get through the smallest capi ... Read More
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A 31-year-old member asked:
Dr. Ritesh Rathore
29 years experience Hematology and Oncology
Chronic: Treatment focus is on maintaining hemoglobin levels, preventing "sickle crises", and preventing complications. Depending on blood levels and frequency ... Read More
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