Question 1

please help me? what is krabbe disease?

Accepted Answer

Krabbe Disease: Or globoid cell leukodystrophy is a rare genetic neurological disorder  affecting the myelin sheath of nerves.

Question 2

can it be possible for you die to from krabbes disease?

Accepted Answer

Early onset: Krabbes Disease (infancy) can be fatal.

Question 3

could you explain what is "krabbe disease" in an easy definition?

Accepted Answer

Krabbe disease: Krabbe disease is degenerative disorder that affects the myelin sheath of the nervous system.

Question 4

what condition is also known as krabbe leukodystrophy?

Accepted Answer

Globoid cell: This is one of the leukodystrophies, a genetic disease, of the nervous system.  Myelin, the covering around nerves, is destroyed causing brain damage. There is a deficiency of the enzyme, galactocerebrosidase. This disease mostly affects infants but can occur at any age. Unfortunately there is no cure.

Question 5

i'm wondering can the embryo be tested for krabbe disease?

Accepted Answer

Yes, PGD is possible: Krabbe disease results when both parents carry a gene for this disease and a child inherits two abnormal genes, one from each parent. We know which gene is responsible for this disease, so Preimplantation Genetic Diagnosis (PGD) where we test embryos for the disease before replacing disease-free embryos or carriers back into the mother's uterus, should be possible. This is a form of IVF treatment.

Question 6

is optic nerve enlargement for someone with krabbe disease possible?

Accepted Answer

No: Optic atrophy.  If there is enlargement there is another disease process.

Question 7

do genetics play a big role in krabbe disease?

Accepted Answer

Yes: Krabbe is a genetic inherited condition.  It is inherited in an autosomal recessive fashion.  That means that for a patient with krabbe, both parents are usually carriers of the abnormal gene called galc.  Those parents will have a 25% chance of having another affected child and a 50% chance of having children that are carriers.

Question 8

what is krabb disorder?

Accepted Answer

Krabbe disease: Is a rare genetic disorder of the nervous system due to mutation in chromosome no. 14, where there is loos of myelin sheath of nerves leading to stiffness, seizures, loss of muscle strength. It usually starts at 2-6 month age. If early, treatment is bone marrow transplant and physical therapy to strengthen muscles.

Question 9

is lou gehrig's disease hereditary?

Accepted Answer

Some are: Research shows that about 5% of cases are hereditary.

Question 10

is lou gehrig's disease dominant or recessive?

Accepted Answer

Neither: 90-90% of case of ALS are not inherited, it occurs at random at its cause is not known. In 5-10% of cases there is a familial form of the disease. In these 5-10% of cases it is usually dominant  (meaning it is only necessary to have one copy of the defective gene) remember however most of the time it is not inherited at all.

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Doctor answers about:

Krabbe

A member asked:

Please help me? what is krabbe disease?

A member asked:

Can it be possible for you die to from krabbes disease?

A member asked:

Could you explain what is "krabbe disease" in an easy definition?

A member asked:

What condition is also known as krabbe leukodystrophy?

A member asked:

I'm wondering can the embryo be tested for krabbe disease?

A member asked:

Is optic nerve enlargement for someone with krabbe disease possible?

A member asked:

Do genetics play a big role in krabbe disease?

A member asked:

What is krabb disorder?

A member asked:

Is lou gehrig's disease hereditary?

A member asked:

Is lou gehrig's disease dominant or recessive?

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