Question 1

is myelofibrosis. hereditary?

Accepted Answer

Almost never: Common myelofibrosis and its cousin myeloid metaplasia are almost always sporadic. There are a few genetic marrow-failure syndromes but these are fairly easy to recognize.

Question 2

what is  myelofibrosis?

Accepted Answer

Myelofibrosis: A blood disorder which usually affects the bone marrow causing anemia and low counts, and cause spleen enlargement and other constitutional symptoms like weight loss, malaise, risk of infection and bleeding. It can lead to leukemia or a bone marrow failure syndrome. Bone marrow transplant in young patients can be considered. Jakafi (ruxolitinib) is a new drug approved to treat symptoms of myelofibrosis.

Question 3

is danogal for myelofibrosis?

Accepted Answer

Danazol perhaps?: Myelofibrosis (mf) is a blood condition where the bone marrow is replaced by scar tissue (fibrosis).  One problem that develops is anemia.  Medications related to testosterone (androgens) sometimes help.  Danazol is one such drug.  It has many other uses.  Other drugs for mf include jak2 inhibitors, thalidomide derivatives, epoietin and hydroxyurea.

Question 4

what is prognosis for myelofibrosis?

Accepted Answer

Depends: They are several phases of the disease and it depends on how much fibrosis is present in the marrow.  Since this is included in the group of disorders known as myeloproliferative neoplasms, it can develop into a leukemia.  Hope this was helpful.

Question 5

tell me about chronic idiopathic myelofibrosis?

Accepted Answer

Pmf: A condition where  there is a significant and uncontrolled growth/increase of reticulin fibre inside thebone marrow resulting in  decrease production of normal blood cells inside the. One matrow, increase production of hematopoietic cells outside the bone marrow, and if severe enough also associated with weight loss, bony pain, increase spleen size, malaise etc. Bone marrow transplant is to cure

Question 6

is there a complete cure for myelofibrosis?

Accepted Answer

Transplant: The only potential cure for myelofibrosis is an allogeneic stem cell transplant.  This requires a stem cell donor and cannot be done with the patient's own stem cells.

Question 7

is idiopathic myelofibrosis a form of leukemia?

Accepted Answer

No: Primary idiopathic myelofibrosis is under umbreall of myeloproliferative neiplasm-where for some unknown reasons, there is uncontrolled increased production of reticulin fibres inside the bone marrow space. While it is not a form of leukemia, however it can transform into acute leukemia.

Question 8

how do you treat myelofibrosis on the 69-year-old male?

Accepted Answer

Multiple options: Depending on symptoms, options include transfusions, drugs to stimulate red cell production (erythropoietin, androgens), thalidomide derivatives (lenolidomide, pomalidomide), jak2 inhibitors (jakafi), splenectomy, radiation therapy, chemotherapy (hydroxyurea) or bone marrow transplant.

Question 9

i've been told my life expectancy is around 5 years. what course will myelofibrosis take to ultimately lead to my death? why my prognosis now terminal

Accepted Answer

Myelofibrosis: I am so very sorry to hear of this diagnosis.
I have cared for people over several decades as their doctor with this horrible disease.  It has no known cause and no effective treatment.   It is a scarring of the bone marrow leading to inability to produce life saving red blood cells, white blood cells and platelets.  See  if a large center (if near one) that specializes in clinical trials can help

Question 10

what cancer would cause myelofibrosis in a 57 year old woman?

Accepted Answer

It is a disease: Myelofibrosis is a type of cancer itself although initially it may not show Cancer cells initially. Most such patients develop Leukemia after a period of one to two years. Go see a hematologist if you need further help

Get Virtual Care

For Businesses

About Us

HealthTap Online Primary Care Doctors Accepting New Patients

Doctor answers about:

Is myelofibrosis hereditary

A member asked:

Is myelofibrosis. hereditary?

A member asked:

What is myelofibrosis?

A member asked:

Is danogal for myelofibrosis?

A member asked:

What is prognosis for myelofibrosis?

A member asked:

Tell me about chronic idiopathic myelofibrosis?

A member asked:

Is there a complete cure for myelofibrosis?

A member asked:

Is idiopathic myelofibrosis a form of leukemia?

A member asked:

How do you treat myelofibrosis on the 69-year-old male?

A member asked:

I've been told my life expectancy is around 5 years. what course will myelofibrosis take to ultimately lead to my death? why my prognosis now terminal

A member asked:

What cancer would cause myelofibrosis in a 57 year old woman?

HealthTap Online Primary Care Doctors Accepting New Patients

Telemedicine

Primary Care

Manage Your Conditions

Women's Health

Children's Health

Men's Health

Senior Health

Wellness, Prevention & Lifestyle

Sexual Health

Mental & Behavioral Health

Travel Medicine

Urgent Care

Didn't find what you're looking for?

More of what we treat

Allergies

Antibiotics

Asthma

High Blood Pressure

Prescriptions

Type 2 Diabetes

For Businesses

Company

Health Content

Join Us

Download HealthTap

Questions?