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A 35-year-old member asked:

What is myelofibrosis?

1 doctor answer1 doctor weighed in
Dr. Aasim Sehbai
Hematology and Oncology 24 years experience
Myelofibrosis: A blood disorder which usually affects the bone marrow causing anemia and low counts, and cause spleen enlargement and other constitutional symptoms like weight loss, malaise, risk of infection and bleeding. It can lead to leukemia or a bone marrow failure syndrome. Bone marrow transplant in young patients can be considered. Jakafi (ruxolitinib) is a new drug approved to treat symptoms of myelofibrosis.

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A 46-year-old member asked:

Is danogal for myelofibrosis?

1 doctor answer2 doctors weighed in
Dr. Martin Rubenstein
Hematology and Oncology 45 years experience
Danazol perhaps?: Myelofibrosis (mf) is a blood condition where the bone marrow is replaced by scar tissue (fibrosis). One problem that develops is anemia. Medications related to testosterone (androgens) sometimes help. Danazol is one such drug. It has many other uses. Other drugs for mf include jak2 inhibitors, thalidomide derivatives, epoietin and hydroxyurea.
A 30-year-old member asked:

Can myelofibrosis be fixed?

1 doctor answer1 doctor weighed in
Dr. Aasim Sehbai
Hematology and Oncology 24 years experience
Myelofibrosis: Difficult disease to fix, if can be managed. Young patients bone marrow or stem cell transplant is an option.
India
A 27-year-old female asked:

Why myelofibrosis occur?

1 doctor answer1 doctor weighed in
Dr. Martin Rubenstein
Hematology and Oncology 45 years experience
Stem cell damage. : Myelofibrosis is associated with damage to dna of bone marrow stem cells. This results in abnormal growth and functioning of these cells. The most common gene mutation is in jak2 where a tiny change in the gene drives the abnormal growth, but there other mutations that occur. Mf is one of the myeloproliferative neoplasias, all caused by similar gene damage.
Australia
A 32-year-old female asked about a 31-year-old male:

Is myelofibrosis. Hereditary?

1 doctor answer1 doctor weighed in
Dr. Ed Friedlander
Pathology 44 years experience
Almost never: Common myelofibrosis and its cousin myeloid metaplasia are almost always sporadic. There are a few genetic marrow-failure syndromes but these are fairly easy to recognize.

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Last updated Oct 13, 2016

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