Question 1

what is the human genome project?

Accepted Answer

The Human Genome: Project (HGP) was an international scientific research project with the goal of determining the sequence of chemical base pairs which make up human DNA, and of identifying and mapping all of the genes of the human genome from both a physical and functional standpoint.

Question 2

is the human genome project a disease?

Accepted Answer

No: It was a billion-dollar project to find out about the genes which humans have.  The information has markedly increased our knowledge about the causes and treatments for human disease.

Question 3

what is the human genome project and whose genome was sequenced?

Accepted Answer

Map of Human DNA: The Human Genome Project created a map of human DNA and was completed in 2003.  Anonymous samples were donated by several people, but the majority of the "genome map" is from a single male donor from Buffalo, NY.  The identity of this individual is not known by researchers who sequenced the DNA.

Question 4

how has human genome project helped so far? has anyone had direct benefit?

Accepted Answer

Targeted drugs: As the genetic basis of diseases is discovered, drugs can be targeted for more specific purposes.

Question 5

how are draft sequence and finished sequence in relation to human genome project different?

Accepted Answer

Incomplete versus : In 2000, the human genome project announced an assembled working draft of the sequence of the human genome. They assembled over lapping fragments covering 97% of the human genome. The draft was much more complete than they had expected--over 22.1 billion base pairs of raw sequence data totaling 7-fold sequence coverage. 24% was completely finished, and 50% in near-finished or better form.

Question 6

what do we know about parkinson's as a result of the human genome project?

Accepted Answer

Several genes: There is a very active effort to find genetic causes of parkinson's disease. There is a research study called progeni that has more information on the site. http://progeni.iu.edu

currently the genes associated with parkinson's are alpha-synuclein (snca) & lrkk2 for dominant inheritance and parkin, pink1 & dj-1 for recessive inheritance.

Question 7

grandpa has parkinson's and i don't know anything about the human genomes! can someone help?

Accepted Answer

Clinical Facts: Before overt physical symptoms begin, one can experience pre-motor parkinson's issues: the most reliably reported 4 are chronic constipation, chronic depression, anosmia (part or complete loss of smell--which also effects taste appreciation) & rbd. Rbd stands for rem behavior disorder. Rem  (dreaming stage sleep) can be accompanied by acting-out of dreams: talking, kicking, punching, running, etc.

Question 8

should i have my genome tested? i am single, young, healthy, curious

Accepted Answer

Why?: If you are otherwise healthy and have no significant family hx for rare or genetic  diseases which can be specifically tested for.  But to shotgun has many downsides.  Let us say you have a gene that doubles the likelyhood of a bad problem, but the chances are still better you won't get .It.  You will worry all your life!  for what reason, when you can be hit by a car tomorrow!

Question 9

can diagnosis be made by whole genome sequencing?

Accepted Answer

Depends: Whole genome sequencing may be useful in making diagnosis of inherited disorders. Vast majority of the illnesses neither require this test nor will this test be diagnsostic.
Have a healthy diet, exercise 30 minutes/day, drink plenty of water, have safe sex, no tobacco alcohol weed or street drugs. For nutrition: http://www.choosemyplate.gov/.
Get HPV vaccine. Wish you good health!

Question 10

how much do genes determine health? should we all check genomes?

Accepted Answer

It's variable: For any given disease, there is a contribution of genetics, environment, diet and development.  For rare genetic syndromes like pku, the genetic component is 100% while in type ii diabetes, genetics is about 45%.  I do not recommend whole genome screening as that is often too much information to make rational decisions.  I would suggest genetic susceptibility testing for specific conditions.

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Human genome project advantages and disadvantages

A member asked:

What is the human genome project?

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Is the human genome project a disease?

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What is the human genome project and whose genome was sequenced?

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How has human genome project helped so far? has anyone had direct benefit?

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How are draft sequence and finished sequence in relation to human genome project different?

A member asked:

What do we know about parkinson's as a result of the human genome project?

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Grandpa has parkinson's and i don't know anything about the human genomes! can someone help?

A member asked:

Should i have my genome tested? i am single, young, healthy, curious

A member asked:

Can diagnosis be made by whole genome sequencing?

A member asked:

How much do genes determine health? should we all check genomes?

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