Question 1

what is the implication of chronically elevated compliments 3 and 4 , sed rate c- reactive proteins?

Accepted Answer

Not much: Elevated C3 and C4 have no clinical implications. Sed rate CRP are gross measures of inflammation.

Question 2

is c-reactive protein always elevated in auto immune conditions?

Accepted Answer

No: Myasthenia gravis, multiple sclerosis, Isaac's, and a host of others will usually not feature elevation. Normal C-reactive protein really rules out nothing. It's an adjunct for a field in which history and physical are still primary.

Question 3

what does elevated c reactive protein mean on blood work? mine showed 15 and reference range is 8. should i be concerned?

Accepted Answer

How do you FEEL?: Nobody really knows what to do with this lab. It's ordered by physicians because people with very severe atherosclerosis produce the stuff in the plaques themselves "making it a risk factor". In people who appear otherwise healthy, it's not clear that a mild elevation like this means anything at all. I'd stay fit and stop worrying.

Question 4

why would sed rate be normal but c reactive protein be elevated if they both check for inflammation?

Accepted Answer

Different tests: CRP and Sed Rate are know to respond differently. Sed rate is elevated in bone and skin inflammation while CRP may be normal. Similarly in some inflammations Sed rate may be normal while CRP is elevated.  You may visit this site for a technical publication:
http://file.scirp.org/pdf/ABC_2014021013285184.pdf
Have a healthy diet, exercise, drink plenty of water, have safe sex, and get HPV vaccine.

Question 5

does sed rate and c reactive protein test for the same thing? how can one be normal and one be elevated

Accepted Answer

Inflammatory markers: There are multiple blood tests that test for inflammation, which means that they go up when there is inflammation (like fever, infection, stress) in the body.  Sometimes one marker goes up higher than the other, or goes up before other markers do, which may explain the difference in the levels.

Question 6

i realise that these markers aren't specific but wouldn't most advanced cancers cause elevated sedimentation rate and c-reactive protein?

Accepted Answer

No: Nice to be able to help once again, Matt. The sed rate and especially the C-reactive protein result from the liver pumping out extra large amounts of a couple of particular proteins that are stimulated by very particular things that are often produced in inflammation and seldom in pure neoplasia. Forget most (not all) of what you've read about "immune response to cancer" as myth. Best wishes.

Question 7

my c reactive protein is constantly elevated (~11.6) but my doctor can't find any reason for it. sometimes my cortisol tests high, but all organs test?

Accepted Answer

Stop worrying : This situation is very common and nobody knows what to do about it. Maintain your health like anybody else does, and you can expect the Amanie chances as everyone else of having a good life.

Question 8

i had the following test done my c reactive protein was elevated 6.0 8 was cutoff and my esr was 6 which is normal 20 my last crp was 2.5 back in november all cbc labs normal what caused the slight crp elevation?

Accepted Answer

Normal results: Both your CRP results were normal &amp; slight change within normal limits is also normal as is your ESR. There does not need to be cause because both test are normal. Nowadays, we tend to orer just CRP without ESR as it is probably more accurate measure of inflammation, easier to perform &amp; both usually move in tandem.

Question 9

are c-reactive protein (crp) and esr levels typically elevated with advanced stage cancer such as stage 4 lymphoma?

Accepted Answer

No: These tests are neither sensitive nor specific for much. They generate enormous confusion and unnecessary fear. C-RP is made in atherosclerotic plaques and is often up in bad atherosclerosis. It's also made in the liver in response to some interleukins in disease elsewhere, especially some arthritis variants. Sed rate reflects globulins and fibrinogen, not usually up in lymphoma.

Question 10

what is a the implication is chronically elevated complement 3 and 4 and elevated ige?  plaquenil has lowered sed rate and c reactive protein.

Accepted Answer

Infection?: If you are being treated for lupus, a normal C3 is a good thing.  However when it is elevated, infection may be the cause.  If the IgE is only mildly elevated, it may be from something else such as allergies.  But it is highly elevated, one will need to rule out other medical conditions.  We really need more details re. your symptoms.

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Doctor answers about:

Elevated c reactive protien

A member asked:

What is the implication of chronically elevated compliments 3 and 4 , sed rate c- reactive proteins?

A member asked:

Is c-reactive protein always elevated in auto immune conditions?

A member asked:

What does elevated c reactive protein mean on blood work? mine showed 15 and reference range is 8. should i be concerned?

A member asked:

Why would sed rate be normal but c reactive protein be elevated if they both check for inflammation?

A member asked:

Does sed rate and c reactive protein test for the same thing? how can one be normal and one be elevated

A member asked:

I realise that these markers aren't specific but wouldn't most advanced cancers cause elevated sedimentation rate and c-reactive protein?

A member asked:

My c reactive protein is constantly elevated (~11.6) but my doctor can't find any reason for it. sometimes my cortisol tests high, but all organs test?

A member asked:

I had the following test done my c reactive protein was elevated 6.0 8 was cutoff and my esr was 6 which is normal 20 my last crp was 2.5 back in november all cbc labs normal what caused the slight crp elevation?

A member asked:

Are c-reactive protein (crp) and esr levels typically elevated with advanced stage cancer such as stage 4 lymphoma?

A member asked:

What is a the implication is chronically elevated complement 3 and 4 and elevated ige? plaquenil has lowered sed rate and c reactive protein.

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