Question 1

what is chronic myelogenous leukemia?

Accepted Answer

A blood cancer: CML is a blood cancer that develops slowly (hence chronic).  If untreated it will eventually be life threatening. It is associated a unique chromosomal injury, the philadelphia chromosome. New drugs (tkis) target this damage and reliably produce remissions in early stage patients that often are long lasting.

Question 2

dangers of chronic myelogenous leukemia?

Accepted Answer

Can be fatal: This is a disease that was associated with a shortened life span. The discovery of a specific cancer cell mutation and medications that attack that mutation have dramatically affected the outcome. This is now a disease that people can live for many years and be functional and productive.

Question 3

what is chronic myelogenous leukemia (cml)?

Accepted Answer

White cell cancer: The bone marrow cells that produce granulocytes (needed to fight infections) grow out of control and are present in large numbers in the blood and other organs. The disease is quite treatable these days because of targeted therapy and long lasting remissions are possible in most people.

Question 4

how should i treat chronic myelogenous leukemia?

Accepted Answer

CML: CML is associated with philadelphia chromosome that result in the abnormal bcr-abl fusion gene. This becomes the target of treatment in cml. Oral tyrosine kinase inhibitor (tki) is the treatment of cml. The 1st generation is gleevec. Other tki that is more specific to block the bcr/abl fusion gene also available- sprycel and tasigna (nilotinib). Bone marrow transplant is available only for specific case.

Question 5

what are the tests for chronic myelogenous leukemia?

Accepted Answer

Blood, bone marrow: Common tests include blood review, floww cytometry, and a bone marrowe and biopsy.

Question 6

what are the symptoms of chronic myelogenous leukemia?

Accepted Answer

Fatigue: Fatigue is the most common symptom. Examination may show an enlarged spleen. The diagnosis is suspected by blood testing and confirmed by bone marrow biopsy.

Question 7

what kind of disorder is chronic myelogenous leukemia?

Accepted Answer

Myeloproliferative: It is in a group of disorders referred to as myeloproliferative neoplasms.  There are essentially four:  chronic myelogenous leukemia, essential thrombocytosis, polycythemia rubra vera and myelofibrosis.  Hope this helps.

Question 8

what are different ways to treat chronic myelogenous leukemia?

Accepted Answer

CML: CML is associated with philadelphia chromosome that result in the abnormal bcr-abl fusion gene. This  becomes the target of treatment in cml. Oral tyrosine kinase inhibitor (tki) is the treatment of cml. The 1st generation is gleevec. Other tki that is more specific to block the bcr/abl fusion gene also available- sprycel and tasigna (nilotinib). Bone marrow transplant is available only for specific case.

Question 9

what's the type of inheritance of chronic myelogenous leukemia (cml)?

Accepted Answer

Not inherited: CML is associated with chromosome damage (the philadelphia chromosome).  This is not inherited. The damage is to bone morrow stem cells and occurs long after birth.  So the disease is not passed on to children.

Question 10

what are the tip-offs that you might have chronic myelogenous leukemia?

Accepted Answer

Abnormal labs: Many times- CML is presented with abnormal labs ( cbc)- without any significant symptoms. See your doctor and have a routine blood test done . Sometimes, if the white blood cells count increases so much that supress the other blood counts-i.e. Red cells and platelets- you can have anemia ( fatigue/weak) and bleeding. Also enlargement of spleen can cause bloating, fullness, increase abdominal girth.

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