Question 1

what can cause high ch50 and high c4 and high crp levels ?

Accepted Answer

Complement tests: The complement tests and c reactive protein test you mention are all nonspecific markers of inflammation. Many different conditions may cause elevations of these.   So they can be due to autoimmune conditions, inflammation from cancer or numerous other disease states. It is also common for complement activation to be associated with low levels of c 4, due to consumption of it.

Question 2

can c4 level indicate cancer?

Accepted Answer

No: No. It does not indicate cancer.

Question 3

i have low c3 and c4 with high histamine levels.  what could be the cause?

Accepted Answer

See details: Low C3 and C4 can be seen in numerous conditions or may have no clinical importance at all. The conditions you list would not cause the low values. Why were the tests ordered in the first place? You should address this question to the doctor who ordered the tests.

Question 4

what does it mean when you have high levels of complement c4 and sedimentation rate westergren?

Accepted Answer

Complement C4/ESR: complement C4 and the erythrocyte sedimentation rate are usually high in conditions which cause acute or chronic inflammation. These are often measured in autoimmune diseases and rheumatoid arthritis, but they can be elevated in many other conditions, including cancer and heart attacks. The results need to be interpreted by your physician. Good luck.

Question 5

my c4 complement level is low and c3 complement is at the low end of the range (90, ref range 90-180). what could this mean?

Accepted Answer

May be significant : Low Complement levels may be nonspecific markers for autoimmune disorders. Other symptoms and clinical findings are needed to be able to adequately answer your question.

Question 6

what is the significance of having low serum levels of kappa and lambda free light chains?  i had high ch50 and normal c3 and c4.

Accepted Answer

The: Concern would be low ch50 and low C3 ; c4, like in lupus. Elevations in kappa or lambda  would be of concern for myeloma, not to worry about these levels.

Question 7

can u tell me what symptoms occur from retrolethesis (?sp) of c3 c4? i also have bulged, or herniated dics at every other level in my neck...

Accepted Answer

Retrolisthesis: From wikipedia: "structural instability may be experienced as a local uneasiness or a structural compensatory distortion involving the whole spine. If the joints are stuck in a retrolisthesis configuration there may also be changes to range of motion. Pain may be experienced as a result of irritation to the sensory nerve roots by bone depending on the degree of displacemement.".

Question 8

my mom got back an x-ray report that says that she has degenerative posterior and anterior stair stepping at the c3/c4 levels. what does this mean?

Accepted Answer

Arthritis, slippage: "Degenerative" means something that deteriorated (developed) over time. The stair-stepping means (assuming it was the lateral view) that one vertebra (C3) has moved forward relative to the lower one (C4). How far was not mentioned in the blurb, bu may b given n th full report. This could be a sign of athritis, it may be an inconsequential finding- does ur mom have symptoms? TT the ordering doctor.

Question 9

is a consistantly low c4 complement level but normal c1 inhibitor and functional level  normal for  hae if not in a flare?

Accepted Answer

Low C4: Yes this is normal for some hae patients, a low C4 is a hallmark of hae and you can have normal levels and function of c1 esterase inhibitor in between attacks in some individuals.

Question 10

my family physician suspects i might have hereditary angeoedmia my test came back with high c4 levels and low c1.  can you have high c4 levels w/hea?

Accepted Answer

A bit atypical: A bit more information would be helpful.  How high are your C4 levels and does "low C1" mean C1q or CI-INH.  Were these levels checked during an "attack" or in between "attacks".  High C4 levels are not classic of the various hereditary angioedema variants.

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Doctor answers about:

C4 LEVEL RIGHT AT THE TOP

A member asked:

What can cause high ch50 and high c4 and high crp levels ?

A member asked:

Can c4 level indicate cancer?

A member asked:

I have low c3 and c4 with high histamine levels. what could be the cause?

A member asked:

What does it mean when you have high levels of complement c4 and sedimentation rate westergren?

A member asked:

My c4 complement level is low and c3 complement is at the low end of the range (90, ref range 90-180). what could this mean?

A member asked:

What is the significance of having low serum levels of kappa and lambda free light chains? i had high ch50 and normal c3 and c4.

A member asked:

Can u tell me what symptoms occur from retrolethesis (?sp) of c3 c4? i also have bulged, or herniated dics at every other level in my neck...

A member asked:

My mom got back an x-ray report that says that she has degenerative posterior and anterior stair stepping at the c3/c4 levels. what does this mean?

A member asked:

Is a consistantly low c4 complement level but normal c1 inhibitor and functional level normal for hae if not in a flare?

A member asked:

My family physician suspects i might have hereditary angeoedmia my test came back with high c4 levels and low c1. can you have high c4 levels w/hea?

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