Question 1

i have lupus- diagnosed w/labs and symptoms.but had no antibodies positive- all were 0 except my ssa was 8 (0-40 is neg) & scl-70 was 3 (0-40 neg) should i be concerned about scleroderma? very scared!

Accepted Answer

History & physical: Scleroderma is worth worrying about only if you are having raynaud's. Labs in rheumatology are numerous but are only useful as guides when there's more of the picture than you've shared. A lasting relationship with a rheumatologist who you trust is much better than overstudying labs. Glad you're proactive.

Question 2

possibility of having scleroderma w/ negative scl-70 & negative anti-centromere antibodies?no raynauds,but bad gerd w/ ppi's not workin, i have lupus

Accepted Answer

History / physical: Scleroderma is diagnosed on history and physical exam. Without Raynaud's, it's unlikely. The labs aren't altogether sensitive. I'd address the GERD as a separate issue, and continue as you're probably already doing keeping a close eye on your lupus as a proactive patient. Best wishes.

Question 3

is crest syndrome with high centromere b antibody considered a rare disorder with rheumatologists having only a few such patients?  should i seek out a scleroderma specialty center for regular care?

Accepted Answer

It's your call: I'm glad that you got your diagnosis. It's your call whether to seek a sub-subspecialist. Often your best move is to become scientifically literate and read the real journal articles having to do with your disease. The key decision in your management will probably be whether, when and how to manage any pulmonary arterial hypertension. See if you have someone locally who you like & trust.

Question 4

last year ive got mononucleosis and recently coronavirus. a blood test showed antinuclear antibodies, i have also chronic tonsillitis, my feet feel often cold and i have shortness of breath and tachycardia. what is more likely-lupus or scleroderma?

Accepted Answer

: A positive anti-nuclear antibody test can signal several types of disease, including both systemic lupus and scleroderma.  See a hematologist for definitive testing and an exam to make certain of the diagnosis.

Question 5

what are the antibodies that determine amyopathic dermatomyositis ? what tests should i ask for if has gone into scheloderma?

Accepted Answer

Clinical diagnoses: These are really clinical diagnoses.  Antibodies may provide additional information, but do not determine diagnosis.

Question 6

my test results show possitive for scleroderma scl 70   result  1.1.  im scare is it bad? please help...

Accepted Answer

SCL-70 alone not Scl: The scl-70 is seen in scleroderma but if you look at the total picture - what  does  your  rheumatologist say? The diagnosis of  scleroderma is  not made by having a scl-70. We see this sometimes  in people who do not have scleroderma. It depends on the lab  that performs the  test. Very important is the rest  of the criteria. What  do you have that fits  these. You need to discuss with your rheum.

Question 7

tested positive for 2nd time ana 1:160 centromere on 3/4 n 4/5. tested neg 4  sl-70. what additional test can be done to rule out crest/scleroderma?

Accepted Answer

See details: You keep asking the same question over and over again. There is no additional testing. You either have clinical symptoms consistent with the diagnosis or you do not. If you do not, then you do not have the diagnosis.

Question 8

how many people die from scleroderma?

Accepted Answer

Rare disease: Scleroderma is a very rare autoimmune disease which often results in a progressive decline in health resulting in death, due to the fact that little or no treatment options exist for scleroderma. It is quite rare, among the rarest of all immune complex diseases.

Question 9

what are the 1st symptoms of scleroderma?

Accepted Answer

Tight skin: Early in the disease: fatigue, joint pain, tightening of the skin, and raynaud's phenomenon.

Question 10

what are the possible symptoms of scleroderma?

Accepted Answer

Tight skin: Tight skin is characteristic but there can be a variety of other symptoms such as raynaud's, shortness of breath, chest pain, trouble swallowing, other GI symptoms, etc. Each person with scleroderma has a different set of symptoms and different type of scleroderma involvement.

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Doctor answers about:

Anti scleroderma 70 antibody

A member asked:

I have lupus- diagnosed w/labs and symptoms.but had no antibodies positive- all were 0 except my ssa was 8 (0-40 is neg) & scl-70 was 3 (0-40 neg) should i be concerned about scleroderma? very scared!

A member asked:

Possibility of having scleroderma w/ negative scl-70 & negative anti-centromere antibodies?no raynauds,but bad gerd w/ ppi's not workin, i have lupus

A member asked:

Is crest syndrome with high centromere b antibody considered a rare disorder with rheumatologists having only a few such patients? should i seek out a scleroderma specialty center for regular care?

A member asked:

Last year ive got mononucleosis and recently coronavirus. a blood test showed antinuclear antibodies, i have also chronic tonsillitis, my feet feel often cold and i have shortness of breath and tachycardia. what is more likely-lupus or scleroderma?

A member asked:

What are the antibodies that determine amyopathic dermatomyositis ? what tests should i ask for if has gone into scheloderma?

A member asked:

My test results show possitive for scleroderma scl 70 result 1.1. im scare is it bad? please help...

A member asked:

Tested positive for 2nd time ana 1:160 centromere on 3/4 n 4/5. tested neg 4 sl-70. what additional test can be done to rule out crest/scleroderma?

A member asked:

How many people die from scleroderma?

A member asked:

What are the 1st symptoms of scleroderma?

A member asked:

What are the possible symptoms of scleroderma?

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