1 doctor weighed in:
Methotrexate for rheumatoid arthritis dose it work and anyone had side effects?
1 doctor weighed in

Dr. Thomas Namey
Internal Medicine - Rheumatology
In brief: Yes.
My colleagues believe it is the first choice (acr and eular), but while I use it as a second or third drug, the benefit/risk ratio is incredibly good.
Methotrexate has little or no justification to be taken orally though. Unpredictable absorption, stomach concenbration build up, and going to the liver on first-pass! the liver sees 600x the ultimate concentration in the blood.

In brief: Yes.
My colleagues believe it is the first choice (acr and eular), but while I use it as a second or third drug, the benefit/risk ratio is incredibly good.
Methotrexate has little or no justification to be taken orally though. Unpredictable absorption, stomach concenbration build up, and going to the liver on first-pass! the liver sees 600x the ultimate concentration in the blood.
Dr. Thomas Namey
Dr. Thomas Namey
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