Can being positive for high risk hpv (all numbers except 16,18/45), make you feel 'unwell', tired, run down, affect white blood cell blood tests, etc? or is this virus symptomless other than localised? thank you?

No, HPV cannot cause such symptoms, only localized manifestations.

Agree with Dr. HH. It would be prudent to see your doctor and discuss if you may be depressed. Counter-intuitive as it may seem, exercise may help. Start with low intensity exercise such as walking and gradually increase the intensity as tolerated. Drink more water. Wish you good health!