How can one prevent penile cancer?

Good hygiene & noHPV: Penile cancer is quite rare in the usa, and especially rare in circumcised men. Smegma, the secretions of the foreskin that accumulate underneath the prepuce in uncircumcised males, is proven to be carcinogenic in animals. Human papillomavirus (hpv) infection, which is sexually transmitted, is also likely a co-factor in many cases. So, good hygiene and avoiding penile contact with hpv are how.