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Palm Beach, FL
A 55-year-old male asked:

Can testosterone cream be applied to the scrotum to enhance absorption? will that hurt the testes more than applying a stronger dose on a leg or arm?

4 doctor answers10 doctors weighed in
Dr. Robert Greer
Family Medicine 46 years experience
NO and YES!: The directions are very clear ! do not apply except where directed. Lots of potential problems.Please follow rx directions!
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Madhusudhan Dommeti
Internal Medicine 44 years experience
No: Apply on clean skin, does not have to be scrotum.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Ralph Morgan Lewis
A Verified Doctoranswered
Family Medicine 40 years experience
Application sites: Most sources (including companies making the product & package directions) state specifically not to apply testosterone to scrotum or penis. T can lower sperm counts in larger doses; so direct application to scrotum may do that. Can also irritate scrotum. See image for recommended sites. Inner thighs have highest concentration of t receptors. Avoid fatty areas as fat can convert t to estrogen.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. David Vandersteen
Pediatric Urology 33 years experience
See below: Medication for testosterone replacement therapy come in many varieties (creams, patches, shots). Skin thickness and blood supply vary from location to location, potentially affecting delivery of the drug. Since each drug was tested on a certain location in the body, it is important to follow the instructions on the label for the individual drugs.
Created for people with ongoing healthcare needs but benefits everyone.

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Last updated Nov 2, 2020

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