My breast are in a lot of pain for the last two days. they hurt very bad and my last period was june 15th and my was last depo-provera was in january of this year. they hurt the most when i am cold.

Pregnancy?: Since significant breast tenderness is often a sign of pregnancy, & Depo-Provera is only effective for 3 months as contraception, be sure to do a pregnancy test. Although you have not yet missed a period, sometimes bleeding in early pregnancy can resemble a period. If the pregnancy test is neg, you are probably experiencing premenstrual breast tenderness which will likely resolve with the next period.