A 45-year-old member asked:
Would neurofibromatosis type 1 disqualify me from donating sperm to a sperm bank?
3 doctor answers • 4 doctors weighed in

Dr. Addagada Raoanswered
General Surgery 58 years experience
Yes: You will be disqualified as a sperm donor, during screening process. Sperm bank will not accept people with any genetic disorders. Nf-1 is a genetic disorder involving chromosome 17, formerly known as ' von recklinghausen disease '.
Created for people with ongoing healthcare needs but benefits everyone.
6k viewsAnswered >2 years ago

Dr. Scott McLeananswered
Clinical Genetics 37 years experience
Probably: As you know, neurofibromatosis type 1 (nf1) can affect some people mildly, but in others it can cause serious birth defects. The chance that a sperm donor might pass the nf1 mutation to his biological child is 50% for each pregnancy. This would probably be considered an excessively high risk, so i suspect that sperm (and egg) donors with confirmed nf1 would not be invited to donate.
Created for people with ongoing healthcare needs but benefits everyone.
5.9k viewsReviewed >2 years ago

Dr. Gerald Mandellanswered
Nuclear Medicine 54 years experience
Probably: Therefore 1 in 1500 are new cases.Neurofibromatosis type 1 is considered to have an autosomal dominant pattern of inheritance. People with this condition are born with one mutated copy of the NF1 gene in each cell. In about half of cases, the altered gene is inherited from an affected parent. Estimated incidence of NF1 is 1 in 3000. Approximately half of affected individuals represent first cases in the family as a result of a new genetic event or mutation.
Created for people with ongoing healthcare needs but benefits everyone.
3.4k viewsAnswered >2 years ago
Last updated Sep 28, 2016
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