A member asked:

Hepatitis b vaccine failure: will it lead to chronic hepatitis?

A doctor has provided 1 answer

Failure?: There are some individuals who apparently do not have the capacity to produce antibodies to hepatitis b surface antigen. These are the people who develop chronic hepatitis following acute infection. If you are in this category you may be at risk. On the other hand, if you have received the vaccine and not turned hep b antibody positive you might want to try once more.

Answered 3/24/2012

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