Yes.: Smudge cells are cells that are extremely fragile and easy to disrupt the cell membrane when making a blood smear. Therefore, if the cell is disrupted it can be very hard to identify what kind of cell it is. The most common and well known disease with smudge cells is cll. However, many other hematologic diseases also have smudge cells. Further testing is needed to be sure what cells are there.
Answered 2/16/2019
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