Does marfan syndrome skip generations?

No, but. . .: Marfan synd. Doesn't skip generations, but sometimes it's mild enough that the person who seemed to have skipped the disease actually had a mild case of it. Also, it is possible that a child of a Marfan synd. Parent doesn't inherit the mutation (child is normal), but that child's child or grandchild gets a new mutation or marries a mild, undiagnosed Marfan patient... Leading to future Marfan kids.

Thanks for asking!: Marfan syndrome is a dominant genetic trait, meaning that people who inherit only one copy of the Marfan fbn1 gene from either parent will develop Marfan syndrome and be able to transmit it to their children.