Can i take benadryl (diphenhydramine) severe allergy plus sinus headache with advil?

Maybe: With so many over the counter preparations, one has to be very careful and read the labels carefully to see what the ingredients are. Benadryl (diphenhydramine) is an antihistaminic, but the preparation you are talking about may already include Ibuprofen (advil ) or Aspirin or similar, so more advil is not advised.

Yes you can: Yes you can as Benadryl (diphenhydramine) allergy plus sinus relief does not contain ibuprophen.