Sleepiness for some: For some people, zyrtec can make them a bit sleepy (usually much less than first generation antihistamines like benadryl, (diphenhydramine) though). Taking more than 1 may increase the sleepiness in those persons. Otherwise it is usually safe. However, if your allergies are bad enough that one pill is not enough, you should see your doctor or an allergist to discuss other potential treatment options.
Answered 3/23/2019
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