Can i take benadryl (diphenhydramine) after drinking wine?

Avoid it: Many people are sensitive to Benadryl (diphenhydramine) and the side effects. Drowsiness and disorientation may be cumulative with alcohol.

Benadryl (diphenhydramine) + Wine: Both Benadryl (diphenhydramine) and alcohol (in wine) are central nervous system depressants. Mixing the two will cause additive CNS depression. I would not recommend combining the two, simply because it would be difficult to predict the severity of the additive CNS depressant activity.