Can knee problems cause calf pain?

See below : Yes. If the knee swells this can cause swelling to the back of the knee which can cause an out pocketing which can cause pain from stretching of the tissue. Altered gait (walking)because of the associated knee pain and progressive limited range of motion causing further shortening of the calf muscles causing stiffness. . There are other reasons . Go seek medical attention good luck thank you.

Yes, but: Yes, knee pathology can potentially cause regional radiation of pain into the thigh and calf. However, if you have pain which is isolated to the calf, then the calf should be considered the pain generator until proven otherwise. Calf pain is one potential sign of a blood clot in the leg, so don't hesitate to see a physician for further evaluation.