A member asked:

Besides wellbutrin, (bupropion) what other antidepressants tend to be activating, rather than sedating, in nature?

5 doctors weighed in across 2 answers
Dr. Gebrehana Zebro (formerly Woldegiorgis) answered

Specializes in Internal Medicine

Welbutrin is unique: In that its effect is mediated through dopaminergic system. Not all other antidepressants( ssri and snri )not are sedating . There is a new one out there that has a unique property than the typical ssris called viibryd (vilazodone hydrochloride) . It is new and does not have that much track record. The company claims that the sexual side effect and weight and metabolic profile is better than the mentioned medicine

Answered 9/27/2013

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Antideprresants: Most of the newer antidepressant are well tolerated and not very sedative. It all depends on patient response. Try buspar, Pristiq (desvenlafaxine) or lexapro.

Answered 1/3/2015

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