A 33-year-old member asked:
How long before benadryl (diphenhydramine) sleepiness wears off?
1 doctor answer • 3 doctors weighed in

Dr. Michelle Zetoonyanswered
Sleep Medicine 20 years experience
Hangover: So this depends on a lot of things. Typically i tell people between 12-18 hours if they are overall healthy (remember it is a medication that could be dosed every 6 hours!). Realistically may be more like 24+ hours especially if other medications are being used or someone is older.
Created for people with ongoing healthcare needs but benefits everyone.
4.9k viewsReviewed >2 years ago
Similar questions
A 35-year-old member asked:
When does Benadryl (diphenhydramine) drowsiness wear off?
1 doctor answer • 3 doctors weighed in

Dr. Randy Sussmane Stubbsanswered
Internal Medicine - Sleep Medicine 37 years experience
Benadryl (diphenhydramine): Depending on age, weight, how much you take the effect of drowsiness can wear off at different intervals. Also depends on what other meds you take, including other otc such as coffee.
Created for people with ongoing healthcare needs but benefits everyone.
4.9k viewsReviewed >2 years ago
Last updated Oct 23, 2018
People also asked
Connect with a U.S. board-certified doctor by text or video anytime, anywhere.
24/7 visits - just $44!
50% off with $15/month membership
Disclaimer:
Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.