A member asked:

How long before benadryl (diphenhydramine) sleepiness wears off?

A doctor has provided 1 answer
Dr. Michelle Zetoony answered

Specializes in Sleep Medicine

So this depends on a lot of things. Typically i tell people between 12-18 hours if they are overall healthy (remember it is a medication that could be dosed every 6 hours!). Realistically may be more like 24+ hours especially if other medications are being used or someone is older.

Answered Oct 23, 2018

4.9k views

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