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A 36-year-old member asked:

Why do we give antiestrogen drugs to those who have breast cancer ?

2 doctor answers4 doctors weighed in
Dr. Gurmukh Singh
Pathology 50 years experience
Cancer needs estroge: Some breast cancer need estrogen to grow and their growth can be retarded by anti-estrogenic drugs.
Dr. Andrew Turrisi
Radiation Oncology 48 years experience
Tumor cell: Receptors: are not on all tumors, and are checked for estrogen (er); Progesterone (pr) and now her-2-neu. If er and pr +, anti-estrogens are of some benefit. They cause tumor cells to stop dividing, and tumors to shrink. They are variable in ductal cancers, but very commonly positive in lobular carcinoma.

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A 46-year-old member asked:

Why do we give antiestrogen drugs to women who have breast cancer ?

3 doctor answers10 doctors weighed in
Dr. Carlo Contreras
A Verified Doctoranswered
Surgical Oncology 19 years experience
To slow growth: Most breast cancers are stimulated by estrogen and progesterone, the normal female sex hormones. When deprived of these hormones, the tumors often die. Consequently, breast cancer tumors are tested to find out if they are sensitive to these hormones. If so, medicines to block these hormones are given as part of the cancer treatment for breast cancer.
Dr. Andrew Turrisi
Radiation Oncology 48 years experience
They are used ONLY if the tumor expresses am estrogen/progersterone receptor, an assay done on the tumor when resected, in the path department. These drugs wither block or partially block the receptor, or undo the ability to producse estrogen, a driving force.
May 5, 2012

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