Does antibiotics clear fordyce spots on lips?

Probably Not: Fordyce spots are dilated oil glands on the lips so likely will not resolve with antibiotics, though they may shrink a bit due to the anti-inflammatory properties of antibiotics.

Fordyce Spots: Tretinoin cream is one of the most common treatments used for Fordyce spots. You need to keep in mind is to always remember to apply it to your lips at least three times / day. It is best to apply it to your lips in the morning, noon, and night before going to bed. Vaporizing laser treatments, pulse dye lasers treatment are some other medical treatment options.