What are the concerns for having high alkaline phosphatase?

Liver or bone: Answer can depend on situation. Pregnancy can raise alk phos level. In general, however, the source is either liver or bone and the reason should be determined, since the causes can be treated. There are too many possibilities to list and your doctor will have to determine the source, possibly by doing additional testing. Liver may mean hepatitis or bile duct blockage. Bone can be paget's disease.