A member asked:

Does sickle cell status negative mean am aa?

4 doctors weighed in across 2 answers

Yes.: A normal hemoglobin genotype would be denoted aa, sickle cell trait is denoted as and sickle cell disease is ss.

Answered 8/15/2018

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Dr. Craig MacArthur answered

Specializes in Pediatric Hematology and Oncology

Likely, not absolute: Sickle cell negative can mean that a sickle prep test was performed and no sickle hemoglobin was identified. Alternatively, a hemoglobin electrophoresis test was performed and did not show hemoglobin s. Absence of s make the aa genotype most likely; however, there are many other hemoglobin variants beside hemoglobin s. Examples are c, d, e--these all give negative results on the sickle prep test.

Answered 3/20/2019

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Does high reticulocyte count mean sickle cell crisis?

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