A member asked:

Do antidepressants cause restless legs syndrome?

11 doctors weighed in across 4 answers

Meds can trigger RLS: What "causes" RLS is uncertain. It may be related to genetics, deficiency of iron in the brain, hormonal changes, pregnancy, Parkinson's disease. Medications like antidepressants, antipsychotics, cold and allergy medications can trigger or aggravate rls. Treatment with medication can help diminish symptoms.

Answered 7/8/2019

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Possibly. Could help: Ssris, if stopped abruptly can cause shock like symptoms which could mimic restless legs. Buproprion is an antidepressant which effects brain Dopamine and which may help rls. For RLS caused by nightmares, i often prescribe low dose nortriptyline to lessen the vivid dreams.

Answered 7/8/2019

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Dr. Parham Gharagozlou answered

Specializes in Sleep Medicine

YES: If somebody has a mild RLS antidepressants like ssri Prozac zoloft (sertraline) Celexa etc. Can make it worse to the level that patient feels symptoms. It can be significant in fact.

Answered 1/12/2015

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RESTLESS LEG : Treatments are: dopaminergic , benzodiazepines, anticonvulsants and opioids as the last resort.

Answered 4/2/2019

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