A member asked:

Do antidepressants cause restless leg syndrome?

7 doctors weighed in across 2 answers
Dr. Emily Lu answered

Sometimes: Akisthesia (an inner restlessness that can manifest very much like restless legs syndrome) has been reported as a side effect of some antidepressants like prozac, Paxil (paroxetine) and tricyclic antidepressants. However, it is more commonly seen in patients that are on antipsychotic drugs like haldol.

Answered 12/12/2019

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Yes: Antidepressants among the ssri class (zoloft, paxil, (paroxetine) etc) can cause restless legs syndrome. Other causes include anemia, pregnancy, alcohol use and others.

Answered 9/28/2016

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Are patients often given an antidepressant after leg amputation?

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