Can you take otc ibuprofen with hydrocodone?

Hydrocodone & Ibupro: You can take these two medications together as prescribed, as they are members of two different drug classes. Hydrocodone is a narcotic and Ibuprofen is a NSAID - a non-steroidal anti-infammatory drug. They both have potential side-effects and potential hazards. You should make yourself familiar with them. For instance, nsaids can irritate the gastric lining and cause pain and bleeding.