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A 39-year-old member asked:

Is it safe to take benadryl (diphenhydramine) if i took two 10mg loratadine tablets a few hours ago?

2 doctor answers2 doctors weighed in
Dr. James Ferguson
Pediatrics 47 years experience
Yes: The two are compatible in the short term. Benadryl (diphenhydramine) is potentially sedating, so caution is advised.By the way, studies show the regular adult dose of loritadine is 10 mg and 20 mg is not found to be any more effective.
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Dr. Luis Matos
Pediatric Allergy and Asthma 46 years experience
It may make u Drowsy: The full adult dose of Loratadine in other parts of the world is 20 mg. This amount caused a 12-14% drowsiness rate. The 10 mg dose was tested in the us in order to find a non-drowsy dose and it worked. If your allergy symptoms are controlled with Diphenhydramine (benadryl-50% drowsiness) and not 10 mg loratadine, you can try a second 10 mg dose and it may help with a lot less drowsiness.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Nov 23, 2020

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