Not really known: 4.5% people treated with zoloft (sertraline) had a significant weight gain in one study. Weight gain is more likely if the person is taking zoloft (sertraline) for 6 months or longer. There are some people who experience increased carbohydrate craving on zoloft (sertraline). However, mechanism for weight gain is not well understood.
Answered 9/14/2015
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