A member asked:

How does zoloft (sertraline) lead weight gain?

A doctor has provided 1 answer
Dr. Heidi Fowler answered

Specializes in Psychiatry

Not really known: 4.5% people treated with zoloft (sertraline) had a significant weight gain in one study. Weight gain is more likely if the person is taking zoloft (sertraline) for 6 months or longer. There are some people who experience increased carbohydrate craving on zoloft (sertraline). However, mechanism for weight gain is not well understood.

Answered 9/14/2015

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