A 29-year-old male asked:
what is msi analysis? when and why it should be done for a stage iii-c colon cancer patient before chemotherapy?
2 doctor answers • 6 doctors weighed in
Gastroenterology 37 years experience
May help: The question requires a long answer but the abbreviated version is that certain markers such as msi have used to predict tumor behavior and tailor chemotherapy. If your doctor feel it may help you then it should be done.
Surgical Oncology 20 years experience
Lynch Syndrome: "microsatellite instability" examines if there are defects in gene repair pathways causing cancer. Some of these can be hereditary, and may influence other treatments (such as hysterectomy for endometrial cancer risk in females). Recently, msi status has been used to predict benefit from chemo, although this has been more important for stage ii patients. Talk to your doctor for details!
A 78-year-old member asked:
Colon cancer chemo necessary?
3 doctor answers • 8 doctors weighed in
Pathology 23 years experience
No: Chrmotherapy is used for cancers that have spread beyond the wall of the intestine and into the nodes. For tumors that are confined to the wall of the colon it is not usually needed. For tumors that have spread beyond the wall of the intestine but not in nodes, chemo may be used if tumor is high grade, large size causing obstruction or rupture, is close to margin or has high oncotype DX score.
A 46-year-old member asked:
How does chemotherapy target exactly your colon cancer? Does it kill off a lot of normal colon cells too?
1 doctor answer • 2 doctors weighed in
General Surgery 27 years experience
It doesnt: Chemo works by inhibiting/killing cells which grow faster than normal cells. There are side effects because normal cells divide as a normal function, so yes, normal cells are affected too. The trick is to give enough to kill the bad cells, and not so much that the side effects are intolerable.
A 64-year-old female asked:
Side effects to chemo. He's being treated for colon cancer stage 4.?
2 doctor answers • 4 doctors weighed in
Hematology and Oncology 20 years experience
Depends on chemo: The side effects of chemotherapy depend on the chemos involved. In general bone marrow suppression (bms) causing lower red blood cells (rbcs) with anemia, lowered wbcs with increased risk of infection, and lowerd platelets with increased risk of bleeding. Oxalipaltin ("o" in folfox) can cause numbness or cold induced nerve pain. Irinotecan ("i" in folfiri) causes diarrhea. Etc...
A 40-year-old male asked:
What stage colon cancer is it if 9 out of 16 lymph nodes involved and is it curable with chemotherapy ?
3 doctor answers • 3 doctors weighed in
A Verified Doctor answered
A 40-year-old male asked:
What is the most effective chemotherapy for stage 3 colon cancer ?
3 doctor answers • 4 doctors weighed in
Hematology and Oncology 23 years experience
Standard of care: Standard of care -adjuvant chemotherapy for stage 3 colon cancer will be a combination of 5-fluorouracil and oxaliplatin or oral Capecitabine and oxaliplatin.
Last updated Nov 9, 2018
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