Number one vitamin supplement to take for acne?

You can do better: Vitamins are unlikely to be nearly so beneficial as topical benzoyl peroxide at least twice daily for two weeks. If this is not enough to clear you, your physician is your best resource. Acne is a serious, chronic, non-lifestyle-related illness that can always be managed, though it is cured only by time. You owe it to yourself to get effective treatment.