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Baton Rouge, LA
A 24-year-old female asked:

Can a positive ana mean adrenal glands are damaged or addison's disease ?

3 doctor answers12 doctors weighed in
Dr. Ed Friedlander
Pathology 44 years experience
Usually not: Most low-titer-positive ana's mean nothing, and no lab means anything except in conjunction with a real human being. Having said this, i'm glad you're thinking of addison's -- lab diagnosis is reasonably easy.
Dr. Joseph Woods
Pathology 28 years experience
Not likely,, : This more likely means an autoimmune disorder like sle, sjogren's syndrome, scleroderma, or polymyositis. Addison's disease is a wasting of the adrenal glands which is often due to an outside source of corticosteroids, etc..
Dr. Susan Wingo
Endocrinology 33 years experience
Not usually: I agree w/ dr woods that ANA is unlikely to be associated w/ addison's or other causes of adrenal failure, but want to clarify that addison's disease specifically refers to destruction of the adrenal glands due to autoimmunity (different target protein than ana) and not to low adrenal function caused by suppression from an outside source of steroids taken for various medical problems.

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Last updated Jan 1, 2021

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