Are motrin and tylenol (acetaminophen) multi symptom safe to take together?

In general yes: Tylenol (acetaminophen) multi symptom has Acetaminophen (pain reliever and fever controller) and medications for cold/flu - Ibuprofen or Motrin is a non-steroidal anti-inflammatory and is okay to take with tylenol, (acetaminophen) although you need to decide why you are taking these medications - pain, fever, stuffy, runny nose, etc - try to minimize the medication you take for the symptoms - talk with your pharmacist.

Who knows?: Orthodoxy might align Motrin & tylenol (acetaminophen) as compatible classes of molecules. Likely no double blinded placebo controlled study of this matter. Therefore safety unknown. One speculation is to minimize exposure of the body to small pharmaceutical synthetics. Tylenol (acetaminophen) & Motrin both purport to treat pain. Use combinations under direction of a doctor.